Francis Gruber (1912–1948) was a French painter and founder of the Nouveau Réalisme school.
He was born in Nancy, the son of stained glass artist Jacques Gruber.
He first exhibited at the age of 18. While other artists were becoming more and more abstract, he preferred to paint human figures that were highly sculpted. He was influenced by Hieronymus Bosch and Albrecht Dürer and the Lorraine engraver Jacques Callot. He became friends with the Swiss artist Alberto Giacometti.
He died in Paris.