Born in Pitigliano, Italy, he received his early training in Florence, where he engraved the frescoes by Andrea del Sarto in SS Annunziata. He studied in Rome, under Paolo Anesi and Giovanni Maria Morandi. From c.1730 he was active in Venice, where he was extensively patronised by British travellers and became friendly with Richard Wilson in 1750-1. He settled in London in October 1752, rapidly achieving great success with his Italianate landscapes. His work was frequently engraved. He designed a series of tapestries for Charles Wyndham, 2nd Earl of Egremont (c.1758, Petworth House, West Sussex, National Trust). On 16 February 1762 he held a sale of his own work, which contained over seventy items. He announced his intention to return to Italy once all the works were sold, returning to Venice on 11 November 1762. He became a member of the Venetian Academy the following year, but in February 1765 returned to England, where he received at least one commission from George III, Finding of Moses (1768, Royal Collection).
He became a founder member of the Royal Academy in 1768, exhibiting there 1769-71 and 1773. He also exhibited at the Free Society of Artists in 1765-6, and 1782, and at the Society of Artists in 1767-8. He returned to Venice in late 1771, and was elected President of the Venice Academy the following year. Shortly thereafter he retired to Florence, where he died.
The Tate owns a portrait of the artist by Richard Wilson (Tate Gallery N03727).
M. Levey, 'Francesco Zuccarelli in England', Italian Studies, XIV, 1959, pp.1-20
E. Einberg and J. Egerton, The Age of Hogarth, Tate Gallery Collections: Volume Two, London 1988, pp.248-9
Jane Turner (ed.), The Dictionary of Art, London and New York 1996, XXXIII, pp.714-16